Celebrating his upcoming marriage to Shruti Manek, the Professor travel with his Lunch Gang buddies to Las Vegas in the Professor’s future father-in-law's King Aire ultimate luxury motor coach; The plan is simple, they’ll park the RV at Caesars Palace, where they plan to relax, go to a casino and celebrate with a few drinks near the hotel pool (little did he know, the plans will be altered). The next morning, Coach, ManCave, and White Doug awaken to find they have no memory of the previous night, and Professor is nowhere to be found. They’re not in the RV as originally planned but find themselves lying in the hot desert sun near what they believe is the Grand Canyon with wild horses licking their faces. ManCave is missing his left earlobe; Godfather is gone; White Doug finds his left forearm tattooed with a pink heart and ribbons that read “One hell of a night, Love Patrick”.
Following clues, the trio travel to across the desert only to find there in the middle of an Indian Reservation where they discover they were drugged with Crown (top of the Peyote cactus - causing loss of motor skills and memory) they received while watching a tribal ritual of the Havasupai people. At a native rock dwelling some 100 feet above the ground, they also learn that ManCave married the chief’s daughter, Imale. Later the trio is attacked by a band of Havasupai warriors, for trespassing on sacred ground on the reservation. They flee and keep moving across the desert, trying get back to Caesars. During the adventure they discover vultures circling overhead and to their surprise they find Godfather who has been tied naked lying in the sun between cacti for his involvement in trying to steal food from the cave. White Doug then confesses that he drugged everyone’s drinks in the RV ensuring they had could witness Indian culture.
After rescuing Godfather from a sure death, the group hears the distant sound of what they think is thunder, but to their surprise, it’s OM leading a heard of wild horses toward them. Stopping short, OM jumps off his pony and yells out “what’s up bitches, what a night?” Coach says, where you been and how did you get these horses?OM says, funny thing is all I remember is a lying on the bar with the beer tap pouring on me; loud music; and some gangster looking dude told me if I ever want to see my friends again to come with him. Next thing he remembers is he woke up at a horse ranch lying face down in horse shit and mud. Looking around OM jumps on the back of a horse opened the gates and takes off (his Boy Scout survival training kicked in by following the sun) with the other ponies following him. Coach says “You see the rest of the group? Where’s the Professor?” His fiancé is going to kill us if we lost him! The group jumped up on horses and headed west towards Las Vegas along the southern rim of the Grand Canyon.
Meanwhile some 100 miles south, KC, Director and T-Mobile awaken to being buried up to their necks in a sand pit on an Apache reservation. It’s there punishment for trying to impersonate an Indian at the MGM Casino. Does anyone remember what happen? Where’s the rest of our group? As the trio baked in the hot desert sun they see a person walking toward them in the distance that looks familiar. It was Bago! As they yelled for him, Bago motioned with his hands to be quite. See, Bago had a guy on the reservation, who knew a guy that needed some help with a water pump. In exchange, Chief Nahche (the great, great, and grandson of Geronimo) agreed to release the trio after water started to flow. Unaware of their location, Bago negotiated a return to Las Vegas by installing a cellphone tower on the top of ridge.
With the wedding set to occur in 5 hours, Coach calls Shruti and tells her that they cannot find Professor. After a conversation with White Doug, ManCave realizes where the Professor is. The group travels back to the RV at Caesars Palace where they find a delirious and exhausted Professor in the bathroom of the RV. ManCave, Coach, and White Doug had moved him there the night before as a practical joke, screwing the door shut from the outside but promptly forgot where they left him. With less than four hours before the wedding and with no flights to Las Vegas available, the Bago races back to the RV using Chief Nahche’s helicopter. Despite their late arrival, Professor and Shruti are married! ManCave informs the chief’s daughter, Imale that he is already married.
As the reception ends, White Doug finds Coach's digital camera detailing the events they cannot remember, and the group agrees to look at the pictures together before deleting the evidence of their exploits.
